Jinbo Xu,Sheng Wang,Jianzhu Ma's Protein Homology Detection Through Alignment of Markov PDF

By Jinbo Xu,Sheng Wang,Jianzhu Ma

ISBN-10: 331914913X

ISBN-13: 9783319149134

This paintings covers sequence-based protein homology detection, a basic and demanding bioinformatics challenge with various real-world functions. The textual content first surveys a number of renowned homology detection equipment, similar to Position-Specific Scoring Matrix (PSSM) and Hidden Markov version (HMM) established tools, after which describes a singular Markov Random Fields (MRF) dependent technique built by way of the authors. MRF-based tools are even more delicate than HMM- and PSSM-based equipment for distant homolog detection and fold reputation, as MRFs can version long-range residue-residue interplay. The textual content additionally describes the deploy, utilization and outcome interpretation of courses enforcing the MRF-based method.

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Protein Homology Detection Through Alignment of Markov Random Fields: Using MRFalign (SpringerBriefs in Computer Science) by Jinbo Xu,Sheng Wang,Jianzhu Ma


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